Karl Meszaros, MD, PhD

Biography

I am a biomedical scientist with extensive experience in academic research and education, as well as pharmacological research and development. Published widely in the fields of biochemistry, pathophysiology, immunology, and pharmacology.

Education

• Semmelweiss University, Budapest

Research

Metabolic research in diabetes and obesity

Recent Publications

Journal Articles:

1. Mészáros K, Antoni F, Hrabák A, Szikla C, Garzó T, Tompa A, Lapis K. Prevention of the hepatotoxic effects of D-galactosamine by D-galactose. FEBS Lett. 1973 Sep 1;35(1):1-3. 

2. Mészáros K, Antoni F, Mandl J, Hrabák A, Garzó T. Effects of D-galactosamine on nucleotide metabolism and on microsomal membranes in mouse liver. FEBS Lett. 1974 Aug 25;44(2):141-5. 

3. Mészáros K, Mandl J, Antoni F, Garzó T. INhibition of protein synthesis by hexosamine containing glycogen formed in mouse liver after treatment with D-galactosamine. FEBS Lett. 1976 Dec 1;71(2):215-9. 

4. Tompa A, Lapis K, Schaff Z, Mészáros K, Mandl J, Garzó T, Antoni F. Cytoplasmic aggregates in D-galactosamine induced liver injury. Acta Morphol Acad Sci Hung. 1977;25(4):239-57.

5. Mandl J, Garzó T, Mészáros K, Antoni F. Epinephrine and glucagon counteract inhibition of protein synthesis induced by D-galactosamine in isolated mouse hepatocytes. Biochim Biophys Acta. 1979 Sep 3;586(3):560-7.

6. Mészáros K, Chance B, Holtzer H. Myoglobin and cytochrome oxidase in the myocardium of the developing chick. J Mol Cell Cardiol. 1980 Oct;12(10):965-75. 

7. Tihanyi K, Mészáros K, Horváth I. Inhibition of microsomal drug metabolism by mitochondria and cytochrome c oxidation of extramitochondrial NADPH. Biochem Pharmacol. 1982 Mar 1;31(5):661-3.

8. Mandl J, Mészáros K, Antoni F, Spolarics Z, Garzó T. Reversible inhibition of RNA synthesis and irreversible inhibition of protein synthesis by D-galactosamine in isolated mouse hepatocytes. Mol Cell Biochem. 1982 Jul 7;46(1):25-30.

9. Puskás M, Antoni F, Péterfy F, Mészáros K. Pokeweed mitogen, Bordetella pertussis and breast milk cell factor induce preferentially the synthesis of different immunoglobulin classes. Boll Ist Sieroter Milan. 1983 Jul;62(3):262-7.

10. Krasznai A, Arányi P, Fehér T, Krajcsi P, Mészáros K, Horváth I. Alterations in the number of glucocorticoid receptors of circulating lymphocytes in sepsis. Haematologia (Budapest). 1986;19(4):293-8.

11. Krasznai A, Krajcsi P, Arányi P, Mészáros K, Horváth I. Decreased number of steroid receptors of circulating lymphocytes in Crohn'sdisease and ulcerative colitis. Haematologia (Budap). 1986;19(4):299-301.

12. Mészáros K, Bagby GJ, Lang CH, Spitzer JJ. Increased uptake and phosphorylation of 2-deoxyglucose by skeletal muscles in endotoxin-treated rats. Am J Physiol. 1987 Jul;253(1 Pt 1):E33-9.

13. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. Contribution of different organs to increased glucose consumption after endotoxin administration. J Biol Chem. 1987 Aug 15;262(23):10965-70.

14. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues. Biochem Biophys Res Commun. 1987 Nov 30;149(1):1-6.

15. Spitzer JJ, Bagby GJ, Mészáros K, Lang CH. Alterations in lipid and carbohydrate metabolism in sepsis. JPEN J Parenter Enteral Nutr. 1988 Nov-Dec;12(6 Suppl):53S-58S. 

16. Mészáros K, Lang CH, Bagby GJ, Spitzer JJ. In vivo glucose utilization by individual tissues during nonlethal hypermetabolic sepsis. FASEB J. 1988 Dec;2(15):3083-6.

17. Spitzer JJ, Bagby GJ, Meszaros K, Lang CH. Altered control of carbohydrate metabolism in endotoxemia. Prog Clin Biol Res. 1989;286:145-65. 

18. Spitzer JJ, Bagby GJ, Hargrove DM, Lang CH, Mészáros K. Alterations in the metabolic control of carbohydrates in sepsis. Prog Clin Biol Res. 1989;308:545-61. 

19. Mészáros K, Lang CH, Bojta J, Spitzer JJ. Early changes in glucose utilization of individual tissues after endotoxin administration. Circ Shock. 1989 Oct;29(2):107-14.

20. Mészáros K, Lang CH, Hargrove DM, Spitzer JJ. Tissue glucose utilization during epinephrine-induced hyperglycemia. J Appl Physiol. 1989 Nov;67(5):1770-5.

21. de Boisblanc BP, Meszaros K, Cairo J, Spitzer JJ, Summer W. Diaphragmatic fatigue after endotoxemic shock in rats: in vitro function and metabolism. J Med. 1990;21(1-2):7-26.

22. Bautista AP, Mészáros K, Bojta J, Spitzer JJ. Superoxide anion generation in the liver during the early stage of endotoxemia in rats. J Leukoc Biol. 1990 Aug;48(2):123-8.

23. Lang CH, Dobrescu C, Mészáros K. Insulin-mediated glucose uptake by individual tissues during sepsis. Metabolism. 1990 Oct;39(10):1096-107.

24.  Mészáros K, Bojta J, Bautista AP, Lang CH, Spitzer JJ. Glucose utilization by Kupffer cells, endothelial cells, and granulocytes in endotoxemic rat liver. Am J Physiol. 1991 Jan;260(1 Pt 1):G7-12.

25. Spolarics Z, Schuler A, Bagby GJ, Lang CH, Mészáros K, Spitzer JJ. Tumor necrosis factor increases in vivo glucose uptake in hepatic nonparenchymal cells. J Leukoc Biol. 1991 Mar;49(3):  309-12.

26. Mészáros K. Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads. Biochem Biophys Res Commun. 1991 Oct 15;180(1):315-22.

27. deBoisblanc BP, Meszaros K, Burns A, Bagby GJ, Nelson S, Summer WR. Effect of dichloroacetate on mechanical performance and metabolism of compromised diaphragm muscle. J Appl Physiol. 1992 Mar;72(3):1149-55.

28. Mészáros K, Parent JB, Gazzano-Santoro H, Little R, Horwitz A, Parsons T, Theofan G, Grinna L, Weickmann J, Elsbach P, et al. A recombinant amino terminal fragment of bactericidal/permeability-increasing protein inhibits the induction of leukocyte responses by LPS. J Leukoc Biol. 1993 Dec;54(6):558-63.

29. Elsbach P, Weiss J, Doerfler M, Shu C, Kohn F, Ammons WS, Kung AH, Meszaros K, Parent JB. The bactericidal/permeability increasing protein of neutrophils is a potent antibacterial and anti-endotoxin agent in vitro and in vivo. Prog Clin Biol Res. 1994;388:41-51. 

30. Theofan G, Horwitz AH, Williams RE, Liu PS, Chan I, Birr C, Carroll SF, Mészáros K, Parent JB, Kasler H, et al. An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity. J Immunol. 1994 Apr 1;152(7):3623-9.

31. Gazzano-Santoro H, Mészáros K, Birr C, Carroll SF, Theofan G, Horwitz AH, Lim E, Aberle S, Kasler H, Parent JB. Competition between rBPI23, a recombinant fragment of bactericidal/permeability-increasing protein, and lipopolysaccharide (LPS)-binding protein for binding to LPS and gram-negative bacteria. Infect Immun. 1994 Apr;62(4):1185-91.

32. Mészáros K, Aberle S, Dedrick R, Machovich R, Horwitz A, Birr C, Theofan G, Parent JB. Monocyte tissue factor induction by lipopolysaccharide (LPS): dependence on LPS-binding protein and CD14, and inhibition by a recombinant fragment of bactericidal/permeability-increasing protein. Blood. 1994 May 1;83(9):2516-25.

33. Mészáros K, Aberle S, White M, Parent JB. Immunoreactivity and bioactivity of lipopolysaccharide-binding protein in normal and heat-inactivated sera. Infect Immun. 1995 Jan;63(1):363-5.

34. Luo J, Chuang T, Cheung J, Quan J, Tsai J, Sullivan C, Hector RF, Reed MJ, Meszaros K, King SR, Carlson TJ, Reaven GM. Masoprocol (nordihydroguaiaretic acid): a new antihyperglycemic agent isolated from the creosote bush (Larrea tridentata). Eur J Pharmacol. 1998 Apr 3;346(1):77-9.

35. Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Brignetti D, Luo J, Khandwala A, Reaven GM.  Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes. Diabetologia. 1999 Jan;42(1):102-6.

36.  Reed MJ, Meszaros K, Entes LJ, Claypool MD, Pinkett JG, Gadbois TM, Reaven GM. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism. 2000 Nov;49(11):1390-4. 

37. Mészáros, K., M. Barnett, H. Wehring, D. Evans, D. Sasaki-Hill, P. Goldsmith, and K. Knapp. Progress examination for assessing students’ readiness for advanced pharmacy practice experiences. Am J Pharm Educ 2009 Sep;73(6) Article 109

38. Interprofessional Education: Cooperation Among Osteopathic Medicine, Pharmacy,and  Physician Assistant Students to Recognize Medical Errors. Károly Mészáros, MD, PhD; Ingrid C. Lopes, DO; Paul C. Goldsmith, PhD; and Katherine K. Knapp, PhD.  J Am Osteopath Assoc. 2011;111(4):213-218

39.  Pharmacy School Survey Standards Revisited. Károly Mészáros, Mitchell J. Barnett, Russel V. Lenth,  Katherine K. Knapp. Am J Pharm Educ 2013, 77(1), 3. doi: 10.5688/ajpe7713

40. Alternative Viewpoint: Preparation for Residency. Katherine K. Knapp, Károly Mészáros, Paul C. Goldsmith, Gordon C. McCarter, Elizabeth Kelly Hester, et al.  Pharmacotherapy  2014; 34(8):e157–e158; doi: 10.1002/phar.1475

Book Chapters:

Antoni F., and K. Mészáros. Immunopeptides, peptide antigens.  In: Biomedical Significance of Peptide Research. Eds. F. Laszlo and F. Antoni.  Publishing House of the Hungarian Academy of Sciences, Budapest, p. 115-125, 1984.

Spitzer, J. J., G. J. Bagby, D. M. Hargrove, C. H. Lang, and K. Mészáros.  Alterations in the metabolic control of carbohydrates in sepsis.  In: Progress in Clinical Biological Research. Eds. E. Schlag and H. Redl. A. R. Liss, New York, 308: 545-561, 1989.

Spitzer, J. J., J. Bojta, C. H. Lang, and K. Mészáros. Cellular metabolic responses in endotoxemia and a hypothesis for the mechanism of hepatic failure in endotoxin shock. In: Shock, Trauma, Sepsis and Organ Failure. Eds G. Schlag, H. Reidl, J. H. Siegel. Springer Verlag, New York. p. 278-303, 1990. 

Spitzer, J. J., K. Mészáros, A. Bautista, C. H. Lang, and Z. Spolarics.  Potential contribution of phagocytic cells to liver damage after E. coli endotoxin.  In: Cellular and Molecular Aspects of Endotoxin Reactions. Vol. 1. Eds A. Novotny, J. J. Spitzer, and E. J. Siegler. Elsevier, New York,. p. 521-528, 1990.

Spitzer, J. J., Z. Spolarics, A. P. Bautista, K. Mészáros, A. Schuler, and C. H. Lang.  Increased glucose uptake and superoxide anion production after priming or activation of hepatic phagocytes: a potential source of liver damage.  In: Shock, Trauma, Sepsis and Organ Failure. Eds G. Schlag, H Reidl, J. H. Siegel, and D. L. Traber.  Springer Verlag, New York. p. 235-249, 1991. 

Conlon, P. J., H. Gazzano-Santoro, K. Mészáros,  R. Little, K. Huang, J. Watkins, S. Aberle, H. Kasler, D. Fishwild, G. Theofan, A, Horwitz and  J. B. Parent.  rBPI23: A potent bactericidal and anti-endotoxin agent.  In: Mediators of Sepsis. Eds J.-D. Baumgartner, T. Calandra, J. Carlet. Medicine-Sciences Flammarion, Paris. p. 23-35, 1993.
Elsbach, P., J. Weiss, M. Doerfler, C. Shu, F. Kohn, W. S. Ammons, A. H. C. Kung, K. Mészáros, J. B. Parent, H. Gazzano-Santoro, K. Huang, and D. Fishwild.  The bactericidal/permeability increasing protein of neutrophils is a potent antibacterial and anti-endotoxin agent in vitro and in vivo.  In: Bacterial Endotoxins. Basic Science to Anti-Sepsis Strategies. Eds Levin, J., van Deventer, S. J .H., van der Poll, T., and Sturk, A.  Wiley-Liss, New York,  p. 41-51, 1994.

Mészáros, K., K. Huang, H. Gazzano-Santoro, R. Dedrick, and J. B. Parent.  Inhibition of the effects of LPS on endothelial cells by rBPI21 Cys, a recombinant fragment of bactericidal/permeability increasing protein.  In: Immune consequences of Trauma, Sepsis and Endotoxicosis. Ed. Faist, J.  Springer, Berlin, Heidelberg, New York, p. 146-154, 1996.

Recent Presentations:

Differential Utilization of Glucose and Fructose for De Novo Lipogenesis (DNL) in Intestinal Epithelial Cells and Liver Cells. Károly Mészáros, Grace Marie Jones, Ewan Sinclair, Peter Scherp, Jean-Marc Schwarz. Poster presented at the Word Congress on Insulin Resistance, Los Angeles, November 2014.

Fructose-Induced Crabtree Effect: Inhibition of Respiration and Stimulation of Glycolysis in HepG2 Cells. Shona A. Mookerjee and Károly Mészáros.  Poster presented at the Word Congress on Insulin Resistance, Los Angeles, November 2019.

Teaching Responsibilities

Biology, Pathophysiology, Pharmacology